LEARNING SUMMARY

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Online references accessed January 2025

SolpaOne 1000 mg Effervescent Tablets (P) contain paracetamol. For short term symptomatic treatment of mild to moderate pain and/or fever. Adults and children over 16 years and weighing over 50 kg: 1 tablet dissolved in water every 6 hours as needed. Max 4 tablets in 24 hours. Do not use in children under 16 years and weighing less than 50 kg. Do not take with other paracetamol-containing products. In case of overdose, seek immediate medical advice, even if the patient feels well. Contraindications: known hypersensitivity to the ingredients. Caution: renal or hepatic impairment, chronic alcoholism, non-cirrhotic alcoholic liver disease, Gilbert’s syndrome, haemolytic anaemia, dehydration or chronic malnutrition, glucose-6-phosphate dehydrogenase deficiency, paracetamol can interfere with laboratory tests. Product contains sodium (1 tablet equivalent to 26.68% recommended daily intake) and sorbitol. Interactions: probenecid, cholestyramine, rifampicin, carbamazepine, phenytoin, phenobarbital, primidone, warfarin and other coumarins, salicylamide, metoclopramide, domperidone, isoniazid, flucloxacillin, St John’s wort, and chloramphenicol. Side effects: hypersensitivity reaction, angioedema, anaphylactic shock, aspirin-sensitive bronchospasm, platelet disorders, stem cell disorders, thrombocytopenia, leukopenia, haemolytic anaemia, pancytopenia, methaemoglobinaemia, agranulocytosis, hepatic failure, hepatic necrosis, hepatitis, severe renal impairment, gastrointestinal haemorrhage, hypoglycaemia, Interstitial nephritis and serious skin reactions. PL 36390/0411. MAH: Cipla (EU) Limited Dixcart House, Addlestone Road, Bourne Business Park, Addlestone, Surrey, KT15 2LE, UK. Date of preparation: 06/2023. RRP (ex. VAT): 12s £5.19.
SPC: https://mhraproducts4853.blob.core.windows.net/docs/b1f8915cc220cd826a7923fe89c9578e12975241

Solpadeine Plus Soluble Tablets, Paracetamol 500mg, Codeine Phosphate Hemihydrate 8mg, Caffeine 30mg (P) contain paracetamol, codeine phosphate hemihydrate and caffeine. For the treatment of acute moderate pain which is not relieved by paracetamol or ibuprofen alone, including migraine, headache, backache, rheumatic pain, period pain, dental pain, strains & sprains, sciatica. Adults: 2 tablets dissolved in water every 4-6 hours as needed. Max 8 tablets in 24 hours. Adolescents 16-18 years: 1-2 tablets dissolved in water every 6 hours as needed. Max 8 tablets in 24 hours. Adolescents 12-15 years: 1 tablet dissolved in water every 6 hours as needed. Max 4 tablets in 24 hours. Do not give to children under 12 years. Do not take for more than 3 days without consulting a doctor. Do not take any other paracetamol or codeine containing products concurrently. Can cause addiction. Use for 3 days only. In case of overdose, seek immediate medical advice, even if the patient feels well. Contraindications: Known hypersensitivity to ingredients, pregnancy, lactation, rare hereditary intolerance to some sugars, known CYP2D6 ultra-rapid metabolisers, patients 0-18 years who undergo tonsillectomy and/or adenoidectomy for obstructive sleep apnoea syndrome, respiratory depression, and chronic constipation. Caution: Severe renal or hepatic impairment, non-cirrhotic alcoholic liver disease, obstructive bowel disorders, previous cholecystectomy, acute abdominal conditions, asthma, use in the elderly or adolescents weighing less than 50kg, salt restricted diet, gilberts syndrome, glucose-6-phosphate dehydrogenase deficiency, haemolytic anaemia, glutathione deficiency, dehydration, chronic malnutrition, hypotension, hypothyroidism, head injury, raised intracranial pressure. Interactions: warfarin or other coumarins, domperidone, metoclopramide, colestyramine, monoamine-oxidase inhibitors, flucloxacillin, probenecid, sedatives, pregabalin and gabapentin. Avoid excessive caffeine intake. Side effects: Thrombocytopenia, agranulocystosis, anaphylaxis, cutaneous hypersensitivity reactions, hepatic dysfunction, GI disturbance, dizziness, hyperalgesia, bronchospasm, sterile pyuria, dependency or worsening of headache following prolonged use. PL 02855/0080. MAH: Omega Pharma Ltd, Wrafton, Braunton, Devon, EX33 2DL UK. Revision date: 08/2023. RRP (excl. VAT): 24s £7.60
SPC: https://mhraproducts4853.blob.core.windows.net/docs/cbef35f2d6779637fdd88fd9a1ca0b762cd265fb

Solpadeine Max Soluble Tablets, Paracetamol 500mg, Codeine Phosphate Hemihydrate 12.8mg, Caffeine 30mg (P) contain paracetamol, codeine phosphate hemihydrate and caffeine. For the treatment of acute moderate pain which is not relieved by paracetamol or ibuprofen alone, including headache, migraine, dental pain, period pain, strains & sprains, backache, arthritic & rheumatic pain and sciatica. Adults: 2 tablets dissolved in water every 4-6 hours as needed. Max 8 tablets in 24 hours. Adolescents 16-18 years: 1-2 tablets dissolved in water every 6 hours as needed. Max 8 tablets in 24 hours. Adolescents 12-15 years: 1 tablet dissolved in water every 6 hours as needed. Max 4 tablets in 24 hours. Do not give to children under 12 years. Do not take for more than 3 days without consulting a doctor. Do not take any other paracetamol or codeine containing products concurrently. Can cause addiction. Use for 3 days only. In case of overdose, seek immediate medical advice, even if the patient feels well. Contraindications: Known hypersensitivity to ingredients, pregnancy, lactation, rare hereditary intolerance to some sugars, known CYP2D6 ultra-rapid metabolisers, patients 0-18 years who undergo tonsillectomy and/or adenoidectomy for obstructive sleep apnoea syndrome, respiratory depression and chronic constipation. Caution: Severe renal or hepatic impairment, non-cirrhotic alcoholic liver disease, obstructive bowel disorders, previous cholecystectomy, acute abdominal conditions, asthma, use in the elderly or adolescents weighing less than 50kg, salt restricted diet, gilberts syndrome, glucose-6-phosphate dehydrogenase deficiency, haemolytic anaemia, glutathione deficiency, dehydration, chronic malnutrition, hypotension, hypothyroidism, head injury, raised intracranial pressure. Interactions: warfarin or other coumarins, domperidone, metoclopramide, colestyramine, monoamine-oxidase inhibitors, sedatives, probenecid, flucloxacillin, pregabalin, gabapentin, avoid excessive caffeine intake. Side effects: Thrombocytopenia, agranulocystosis, anaphylaxis, cutaneous hypersensitivity reactions, hepatic dysfunction, GI disturbance, dizziness, hyperalgesia, bronchospasm, sterile pyuria, dependency or worsening of headache following prolonged use. PL 02855/0078. MAH: Omega Pharma Ltd, Wrafton, Braunton, Devon, EX33 2DL UK. Revision date: 08/2023. RRP (excl. VAT): 24s £8.55
SPC: https://mhraproducts4853.blob.core.windows.net/docs/77ade0afe60abc3adae142356050edf6ce59222a