When considering which treatment is most effective, it is important to remember that all medication has advantages and disadvantages, so each patient should be viewed as an individual. It may also be trial and error before a patient finds a treatment that works for them. Pharmacies are well placed to help support patients with depression. However, in order to do so effectively, the focus needs to shift from only offering help to those that ask, to proactively intervening with at-risk patients.

All medication carries the risk of side effects. To support adherence and minimise risks, it is important that pharmacists clearly explain the risks and how to cope if they do occur. Patients signed up to the NMS will be able to discuss this in detail. The most common side effects of SSRIs are gastrointestinal upsets and nausea, which generally pass within a week or so. Initially, the patient may become restless or feel increasingly anxious, and should be referred to the pharmacist.

If a patient has suicidal thoughts, they must be referred immediately to the pharmacist as evidence suggests that there is an increased risk of suicide within the first week of treatment. Antidepressants improve a patient's energy levels before they improve their mood. This is a concern if it provides enough drive to commit suicide.