Analgesics

More cases of life-threatening and fatal opioid toxicity due to accidental exposure to transdermal fentanyl patches, particularly in children, have been reported to the MHRA. Patients should be warned not to exceed the prescribed dose and follow the correct frequency of patch application, paying particular attention to avoid touching the adhesive side of patches, and washing hands after application. Patches must not be cut or exposed to heat (this includes hot baths and showers). 

Old patches must be removed before applying new ones and the old patch must be folded over so the adhesive side adheres to itself, placed in the original sachet and stored safely out of the reach of children. Used patches can cause fatalities. Signs of fentanyl overdose require immediate attention and patches must be removed immediately if severe adverse events occur.

Risk of combustion

The MHRA reminded pharmacy staff that some head lice products are combustible/flammable when on the hair and can ignite, causing serious harm. The MHRA received reports of serious burns associated with Hedrin 4% cutaneous solution and other products where the patient smoked during treatment or came into contact with a naked flame. Not smoking around treated hair and keeping away from open flames or other sources of ignition until the hair is washed are essential.